There are a bunch of really interesting interviews with Alison Bechdel, creator of Fun Home, on the great Bat Segundo Show. (The interviews are here, here, and here.) And here's a video interview with Bechdel, too.
The Onion AV Club published a fascinating, career-spanning interview with Gilbert Hernandez and his brother and Love and Rockets co-creator, Jaime. Below, Hernandez talks about his early experiences with comics.
Check out this print interview with Mat Johnson, author of Incognegro, and the video interview below.
Art Spiegelman discusses Maus and MetaMaus in the video below (and in this NPR podcast).
Art Spiegelman lectures at Sacred Heart University.
Blankets creator Craig Thompson talks about his work in this podcast and in the video below.
An talk by Shortcomings creator Adrian Tomine.
Adrian Tomine on NPR